Castleman disease is a reactive lymph node disease. It can affect all lymph nodes, especially chest lymph nodes. The disease can occur at any age, but is more common in young adults. The disease is more common in women than men. Symptoms include significant enlargement of the deep or superficial lymph nodes. Some cases may have systemic symptoms and multi-system damage. However, most patients have no symptoms. A small number of patients may have lung infection, causing cough, suffocation, weight loss, malaise, and fever. Occasionally chronic anemia or abnormal protein blood is seen. For most cases the prognosis is good after the enlarged lymph nodes are surgically removed.
How is Castleman disease, multicentric treated in practice?