Monoclonal gammopathy of undetermined significance (MGUS) is a type of macroglobulinemia. If MGUS occurs, your body will have an unusually large number of antibodies. These abnormal antibodies or immunoglobulin are abnormal protein. They are also detected in patients of certain cancers. However, MGUS is not cancer. The disease often occurs in the elderly and affects more men than women. Initially symptoms are mild and the condition lasts for several years. With progression of the disease, you will have liver, spleen and lymph nodes enlargement, bleeding and fever, very similar to lymphoma and chronic lymphocytic leukemia. A very small number of MGUS can develop into cancer, such as myeloma or lymphoma. Therefore periodic check-up is important. Alkylating agent and penicillamine can be used treating the disease. Plasmapheresis procedure can be done when necessary.
How is Monoclonal gammopathy of undetermined significance treated in practice?