Flexneri Negri amoeba is a type of amoeba existing in freshwater, mud, dust and corrupted plants. The trophozoites and cysts can invade human body through nasal mucosa when a person touch contaminated water, The amoeba proliferate in nose and then enter brain, causing brain lesion. The condition is known as primary amoebic meningoencephalitis. During the early stage, patients have abnormal sensation of taste and smell. This is a response to amoeba invasion. Subsequent symptoms include severe headache, high fever, vomiting and other symptoms, followed by systemic or localized seizures. Patients have obvious symptoms of meningeal irritation, such as neck stiffness. Progression is rapid and the prognosis is poor.
How is Naegleria infection treated in practice?