Zollinger Ellison syndrome is a condition that one or more tumors develop in the pancreas or duodenum (the first part of small intestine). These tumors cause te stomach to produce too much acid, resulting in peptic ulcers. The tumors are gastrinoma, a neuroendocrine tumor that secretes a hormone called gastrin. Gastrin stimulates the stomach to produce acid. Patients may have chronic abdominal pain and diarrhea, nausea, wheezing, vomiting blood and malnutrition. Proton pump inhibitors (such as omeprazole and lansoprazole) and histamine H2-receptor antagonists (such as famotidine and ranitidine) are used to slow acid secretion.
How is Zollinger Ellison syndrome treated in practice?